𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis, radiofluorination and first evaluation of [18F]fluorophenylsulfonyl- and [18F]fluorophenylsulfinyl-piperidines as serotonin 5-HT2A receptor antagonists for PET

✍ Scribed by Ute Mühlhausen; Wiebke Sihver; Johannes Ermert; Heinz H. Coenen

Book ID
116799428
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
589 KB
Volume
37
Category
Article
ISSN
0969-8051

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis, radiofluorination and first e
Synthesis, radiofluorination and first evaluation of (±)-[18F]MDL 100907 as serotonin 5-HT2A receptor antagonist for PET
✍ Ute Mühlhausen; Johannes Ermert; Matthias M. Herth; Heinz H. Coenen 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 231 KB

In some psychiatric disorders 5-HT 2A receptors play an important role. In order to investigate those in vivo there is an increasing interest in obtaining a metabolically stable, subtype selective and high affinity radioligand for receptor binding studies using positron emission tomography (PET). Co

Synthesis, labelling and first evaluatio
Synthesis, labelling and first evaluation of [18F]R91150 as a serotonin 5-HT2A receptor antagonist for PET
✍ Ute Mühlhausen; Johannes Ermert; Heinz H. Coenen 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 226 KB

## Abstract In psychiatric disorders such as anxiety, depression and schizophrenia, 5‐HT~2A~ receptors play an important role. In order to investigate them __in vivo__ there is an increasing interest in selective and high‐affinity radioligands for receptor binding studies using positron emission to

Synthesis of novel WAY 100635 derivative
Synthesis of novel WAY 100635 derivatives containing a norbornene group and radiofluorination of [18F]AH1.MZ as a serotonin 5-HT1A receptor antagonist for molecular imaging
✍ Matthias M. Herth; Vasko Kramer; Frank Rösch 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 265 KB

## Abstract 5‐HT~1A~ receptors are involved in a variety of psychiatric disorders and __in vivo__ molecular imaging of the 5‐HT~1A~ status represents an important approach to analyze and treat these disorders. We report herein the synthesis of three new fluoroethylated 5‐HT~1A~ ligands (AH1.MZ, AH2

Rapid synthesis of [18F]SR46349B, a pote
Rapid synthesis of [18F]SR46349B, a potent and selective 5-HT2 receptor antagonist
✍ Pingzhong Tan; Joanna S. Fowler; Yu-Shin Ding; David J. Schlyer 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 483 KB

## Abstract F‐18 labeled SR46349B, a highly potent and selective 5‐HT~2~ receptor antagonist, was synthesized as a potential radioligand for PET studies of brain 5‐HT~2~ receptors. Nucleophilic aromatic substitution of __trans__‐1‐(2‐nitrophenyl)‐3‐(4‐methoxymethoxyphenyl)‐2‐propenone (10) with NCA