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Synthesis, Physicochemical Properties, and Cytotoxicity of a Series of 5′-Ester Prodrugs of 5-Iodo-2′-deoxyuridine

✍ Scribed by Milind M. Narurkar; Ashim K. Mitra

Book ID
114421135
Publisher
Springer US
Year
1988
Tongue
English
Weight
511 KB
Volume
05
Category
Article
ISSN
0724-8741

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Five new oligoethylene ester derivatives (9±13) of 5-iodo-2 0 -deoxyuridine (IDU) were synthesized and assayed to determine their lipophilicity by both experimental lipophilicity indices (log K 0 ) and calculated partition coef®cients (CLOGP). In vitro experiments were carried out to evaluate the c