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Synthesis on templates : Regiospecific synthesis of imidazoles

✍ Scribed by Darshan Ranganathan; Firdous Farooqui


Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
276 KB
Volume
25
Category
Article
ISSN
0040-4039

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✦ Synopsis


A new, biomimetic template operated strategy has been developed leading to regiospecific synthesis of imidazoles (CHARTS I 6 II).


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## Abstract A new synthetic approach for the regiospecific alkylation of the 6‐position of the tropane ring system has been developed. Alkylation, desulfonylation and deprotection of tropanes 5 and 12 furnished a series of 6‐__endo__‐alkyltropan‐2‐one derivatives 8a‐e, 15a‐e and 16a‐e (R = Me, Et,