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Regiospecific synthesis of (±)-deoxyanthracyclinones

✍ Scribed by Jhillu Yadav; Paul Corey; Chi-Tung Hsu; Kato Periman; Charles J. Sih


Publisher
Elsevier Science
Year
1981
Tongue
French
Weight
219 KB
Volume
22
Category
Article
ISSN
0040-4039

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The known tetralone 5 has been regiospecifically converted in 10 steps (11% yield) to the 6-deoxy tetracyclic ketone 15. Our sequence includes a novel one-step oxidation of 2 to naphthaldehyde 6, and an unusual enone to phenol isomerization (12 \* 14). Although C-7 functionalization of carbinol 17 f