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A general regiospecific synthesis of (+) 11-deoxyanthracyclinones

✍ Scribed by A.V.Rama Ray; V.H. Deshpande; N.Laxma Reddy

Publisher: Elsevier Science
Year: 1982
Tongue: French
Weight: 201 KB
Volume: 23
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)86946-4

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✦ Synopsis

ATI elegant regwspeczfm approach for the syntheses of ll-dearyanthracyclmones zs described,, invoZvzrg the Duels-Alder reactzon of an appmpmate daene tnth a suztably substztuted naphthalme C-D mng synthon. The anthracycllne antibiotics, daunomycln (la) and adrianycln (l&) are presently of great interest because of their potent activity in the clinical treatment of a variety of hunan

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