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Synthesis of γ-amino[4-11C]butyric acid (GABA)

✍ Scribed by Gunnar Antoni; Bengt Långström

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
280 KB
Volume
27
Category
Article
ISSN
0022-2135

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✦ Synopsis

A one-pot s nthesis of no-carrier added y-amin0[4-~~C]butyric acid (GABA) starting with h drogen [zC]cyanide prepared from [llC]carbon dioxide, is presented. Hydrogen [&]cyanide was trapped in tetrahydrofuradpotassium hydroxide in the presence of the amino polyether Kryptofix 2.2.2. A Michael addition with ethyl a y l a t e followed by a selective reduction and hydrolysis of the resulting amino ester gave [4-' CIGABA. The radiochemical purity of GABA was higher than 99 % and the decay corrected radiochemical yield was 60-65% based on the amount of H["C]CN used. The total synthesis time including purification was around 40 min, counted from the start of the Michael addition reaction.

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