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Synthesis of 4-amino [4-11C]butyric acid (GABA)

✍ Scribed by G. Antoni; P. Malmborg; B. Langström

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
91 KB
Volume
26
Category
Article
ISSN
0022-2135

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✦ Synopsis

The so called fast transmitters either excicatory such as glutamate and aspartate or the inhibitory neuro-transmitter 4-aminobutyric acid (GABA) are involved in a multitude of important regulatory processes in the brain.(l) It may be possible to study some of these processes using [11C]GABA in combination with other tracers and PET. GABA has earlier been labelled with 13N using an enzymatic reaction.(2) We have now developed a one-pot synthesis of no carrier added [4-11C]GABA starting with hydrogen [IlC] cyanide.

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