Synthesis of β-hydroxy-γ-trimethylsilyl-γ-butyrolactone as key chiral building block for preparation of four-carbon chain units having tertiary stereogenic carbon

Asymmetric synthesis of stereodefined α-

Asymmetric synthesis of stereodefined α-alkyl-γ-benzyloxymethyl-β-trimethylsilyl-γ-butyrolactones that serve as an efficient precursor for constructing carbon skeletons having a tertiary or quaternary stereogenic center

✍ Kwangho Kim; Sentaro Okamoto; Yuuki Takayama; Fumie Sato 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 171 KB

The optically active lactone 1 can be transformed to a chiral building block or intermediate for constructing carbon skeletons containing either a tertiary or quaternary stereogenic center by taking advantage of the steric bulk as well as the reactivity of a trimethylsilyl group at the b-position of