✦ LIBER ✦
Asymmetric synthesis of stereodefined α-alkyl-γ-benzyloxymethyl-β-trimethylsilyl-γ-butyrolactones that serve as an efficient precursor for constructing carbon skeletons having a tertiary or quaternary stereogenic center
✍ Scribed by Kwangho Kim; Sentaro Okamoto; Yuuki Takayama; Fumie Sato
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 171 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The optically active lactone 1 can be transformed to a chiral building block or intermediate for constructing carbon skeletons containing either a tertiary or quaternary stereogenic center by taking advantage of the steric bulk as well as the reactivity of a trimethylsilyl group at the b-position of 1.