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Synthesis of β-aminovinylphosphonates by organocatalytic nucleophilic displacement of acetate with amines

✍ Scribed by Cécile Garzon; Mireille Attolini; Michel Maffei


Book ID
104097845
Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
977 KB
Volume
51
Category
Article
ISSN
0040-4039

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## Abstract A highly efficient organocatalytic synthesis of lapachol analogues from the Michael addition of naphthoquinone to various α,β‐unsaturated ketones catalyzed by primary amines is presented. Good to high yields (up to 93 %) and high to excellent enantioselectivities (up to 98 % __ee__) wer