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ChemInform Abstract: Organocatalytic Michael Addition of Naphthoquinone with α,β-Unsaturated Ketones: Primary Amine Catalyzed Asymmetric Synthesis of Lapachol Analogues.

✍ Scribed by Guangcun Zhang; Yifeng Wang; Wei Zhang; Xiangsheng Xu; Aiguo Zhong; Danqian Xu


Publisher
John Wiley and Sons
Year
2011
Weight
31 KB
Volume
42
Category
Article
ISSN
0931-7597

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Organocatalytic Michael Addition of Naph
✍ Guangcun Zhang; Yifeng Wang; Wei Zhang; Xiangsheng Xu; Aiguo Zhong; Danqian Xu 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 443 KB

## Abstract A highly efficient organocatalytic synthesis of lapachol analogues from the Michael addition of naphthoquinone to various α,β‐unsaturated ketones catalyzed by primary amines is presented. Good to high yields (up to 93 %) and high to excellent enantioselectivities (up to 98 % __ee__) wer