Organocatalytic Michael Addition of Naph
✍
Guangcun Zhang; Yifeng Wang; Wei Zhang; Xiangsheng Xu; Aiguo Zhong; Danqian Xu
📂
Article
📅
2011
🏛
John Wiley and Sons
🌐
English
⚖ 443 KB
## Abstract A highly efficient organocatalytic synthesis of lapachol analogues from the Michael addition of naphthoquinone to various α,β‐unsaturated ketones catalyzed by primary amines is presented. Good to high yields (up to 93 %) and high to excellent enantioselectivities (up to 98 % __ee__) wer