Synthesis of β-aminophosphonic acids of cyclohexane, norbornane, and bicyclooctane series
✍ Scribed by N. A. Anisimova; A. A. Kuzhaeva; G. A. Berkova; V. M. Berestovitskaya
- Book ID
- 111459115
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 119 KB
- Volume
- 76
- Category
- Article
- ISSN
- 1070-3632
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The gold(I) catalyzed aldol reaction of diethyl a-isocyanomethylphosphonate with benzaldeyde gave the oxazoline 3, a P-hydroxy-a-aminophosphonic acid precursor, with high enantioand diastereoselectivity (98 % tram, 85 % ee) by employing a chiral ferrocenylamine ligand. The use of 31P NMR spectroscop
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