Synthesis of α,β-unsaturated (S)-cyanohydrins using the oxynitrilase from Hevea brasiliensis
✍ Scribed by Norbert Klempier; Ulrike Pichler; Herfried Griengl
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 240 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0957-4166
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📜 SIMILAR VOLUMES
The Horner-Wittig reaction of cyanomethyl-and carbethoxymethyl diphenylphosphine oxides with a range of O-protected chiral a-hydroxy aldehydes is described. The a-hydroxy aldehydes were prepared with high enantiomeric purity from chiral O-protected cyanohydrins. The g-hydroxy-a,b-unsaturated compoun
Absrruct: (S')-13-Hydroxyoctadeca-(9Z, I I,?)-dienoic acid (1) was synthesized in nine steps starting from (Q-2-octenal (2). The (S)-hydroxynitrile lyase cloned from Hewa brasiliensis, that has been overexpressed in Pi&a pastoris, was used to interconvert 2 into (S)-cyanohydrin 3, The subsequent but
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