Synthesis of α-methylene monosubstituted δ-lactones from α-phosphonolactones new wittig-horner compounds
✍ Scribed by Gioacchino Falsone; Ute Wingen
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 121 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
The synthesis of the a-methylene monosubstitutedGlactones 3-s and 14-18 from -theaphosphonolactones &,2& and the aldehydes 2-5 and 11-13 is described.
📜 SIMILAR VOLUMES
2-Substituted allylsilanes 1 on treatment with iodosobenzene and boron trifluoride etherate in dioxane afforded conjugated enals 2 directly in good yield, from which a-methylene y-and &lactones 7 were synthesized.
## Abstract A new approach to optically active β‐alkyl‐α‐methylene‐δ‐butyrolactone derivatives was reported from the __Rhodococcus__ sp. AJ270‐catalyzed hydrolysis of appropriate nitriles. The inversion of enantioselectivity of the amidase has been observed when a methyl protection was introduced i