✦ LIBER ✦
Synthesis of Optically Active β - Alkyl - α - methylene - δ - butyro -lactones from Enantioselective Biotransformation of Nitriles, an Unusual Inversion of Enantioselectivity†
✍ Scribed by Sheng-Min Zhao; Mei-Xiang Wang
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 704 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0256-7660
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✦ Synopsis
Abstract
A new approach to optically active β‐alkyl‐α‐methylene‐δ‐butyrolactone derivatives was reported from the Rhodococcus sp. AJ270‐catalyzed hydrolysis of appropriate nitriles. The inversion of enantioselectivity of the amidase has been observed when a methyl protection was introduced into the hydroxy group of the parent substrate.