The palladium-catalyzed cross-coupling of o-allylic and o-vinylic phenols with vinylic halides and triflates produces substituted dihydrobenzopyrans and dihydrobenzofurans respectively in good to high yields.
Synthesis of vinylic lactones via palladium-catalyzed coupling of vinylic halides or triflates and unsaturated carboxylic acids
โ Scribed by Richard C. Larock; David J. Leuck; L.Wayne Harrison
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 218 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
Vinylic halides or triflates react with 3-butenoic or 4-pentenoic acids in the presence of 5% Pd(OAc) or Pd(dba) dimethylformamide at 8 -100ยฐC 6
๐ SIMILAR VOLUMES
The palladium-catalyzed cross-coupling of o-allytic and o-vinylic phenols with vinylic halides and triflates produces substituted dihydrobenzopyrans and dihydrobenzofurans respectively in good to high yields. The proposed mechanism involves vinylpalladium addition to the olefin, rearrangement to a g
The palladium-catalyzed cross-coupling of o-vinylic and o-allylic anilides with vinylic halides and triflates produces 2-vinylic dihydroindoles and tetrahydroquinolines respectively in good to high yields.