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Synthesis of Unsymmetrical 1,1′-Disubstituted Bis(1,2,3-triazole)s Using Monosilylbutadiynes

✍ Scribed by Doak, Bradley C.; Scanlon, Martin J.; Simpson, Jamie S.


Book ID
118116096
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
237 KB
Volume
13
Category
Article
ISSN
1523-7060

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## Abstract Aryl azides **1** were treated with allenylmagnesium bromide (**2**) to generate 1,5‐disubstituted butynyl‐1__H__‐1,2,3‐triazoles **3** in a domino fashion, which upon Cu^I^‐catalyzed 1,3‐dipolar cycloaddition with aryl azides **4** afforded novel bis‐1__H__‐1,2,3‐triazoles **5** in qua