A Novel ‘Domino-Click Approach’ to Unsymmetrical Bis-1H-1,2,3-triazoles

✍ Scribed by Abid H. Banday; Bhupinder S. Arora; Mohammed S. Alam; Halmuthur M. Sampath Kumar

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: German
• Weight: 203 KB
• Volume: 90
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200790242

✦ Synopsis

Abstract

Aryl azides 1 were treated with allenylmagnesium bromide (2) to generate 1,5‐disubstituted butynyl‐1__H__‐1,2,3‐triazoles 3 in a domino fashion, which upon Cu^I^‐catalyzed 1,3‐dipolar cycloaddition with aryl azides 4 afforded novel bis‐1__H__‐1,2,3‐triazoles 5 in quantitative yields (Scheme 1 and Table).