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Synthesis of Unique Spin-Labeled Nucleic Acids by Combined Enzymatic and Chemical Approaches

✍ Scribed by Charles R. Toppin; Ingrid E. Thomas; Albert M. Bobst

Publisher
John Wiley and Sons
Year
1983
Tongue
German
Weight
291 KB
Volume
66
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

The synthesis of uridine‐5′‐diphosphate analogs, spin‐labeled either at C(4) or C(5) is reported as well as their enzymatic incorporation into ribonucleic acids, some of which had previously been shown to be potent interferon inducers upon annealing with poly (inosinic acid). Also, the synthesis of spin‐labeled poly (cytidylic acid) obtained by chemical acylation is presented.

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