𝔖 Bobbio Scriptorium
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Synthesis of two arylnaphthalene lignans

✍ Scribed by A.G. González; J.P. Pérez; J.M. Trujillo

Publisher
Elsevier Science
Year
1978
Tongue
French
Weight
238 KB
Volume
34
Category
Article
ISSN
0040-4020

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Convergent synthesis of S-8921, a new po
Convergent synthesis of S-8921, a new potent hypocholesterolemic arylnaphthalene lignan analog
✍ Sachio Mori; Shozo Takechi; Sumio Shimizu; Shiro Kida; Hikozo Iwakura; Makoto Ha 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 177 KB

We established a convergent synthesis of S-8921 (1), a unique hypocholesterolemic lignan analog, in 9 steps, including concise preparations of phthalide 7 and acylpropenoate 10, and their regio-and stereocontrolled tandem anionic reactions leading to precursor 11 as a key step.