Convergent synthesis of S-8921, a new potent hypocholesterolemic arylnaphthalene lignan analog

✍ Scribed by Sachio Mori; Shozo Takechi; Sumio Shimizu; Shiro Kida; Hikozo Iwakura; Makoto Hajima

• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 177 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)02554-4

✦ Synopsis

We established a convergent synthesis of S-8921 (1), a unique hypocholesterolemic lignan analog, in 9 steps, including concise preparations of phthalide 7 and acylpropenoate 10, and their regio-and stereocontrolled tandem anionic reactions leading to precursor 11 as a key step.