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Synthesis of Tryptamine Derivatives via a Direct, One-Pot Reductive Alkylation of Indoles

✍ Scribed by Righi, Marika; Topi, Francesca; Bartolucci, Silvia; Bedini, Annalida; Piersanti, Giovanni; Spadoni, Gilberto

Book ID
115439215
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
414 KB
Volume
77
Category
Article
ISSN
0022-3263

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An expedient synthesis of 3-substituted
An expedient synthesis of 3-substituted indoles via reductive alkylation with ketones
✍ John R. Rizzo; Charles A. Alt; Tony Y. Zhang πŸ“‚ Article πŸ“… 2008 πŸ› Elsevier Science 🌐 French βš– 146 KB

3-Alkylindoles were prepared in one step from indoles and ketones via a convenient reductive alkylation procedure using triethylsilane and trichloroacetic acid. Under this particular condition, unsubstituted indoles could be tolerated to afford good yields of 3-sec-alkylation products.

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