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Synthesis of Tropane Alkaloids via Enantioselective Deprotonation of Tropinone

โœ Scribed by Majewski, Marek; Lazny, Ryszard


Book ID
111960047
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
822 KB
Volume
60
Category
Article
ISSN
0022-3263

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Synthesis of pyranotropanes via enantios
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Synthesis of tropane alkaloids darlingine, chalcostrobamine and isobellendine both in the racemic form and as unnatural enantiomers is described. Enantioselective deprotonation of tropinone, which proceeded with ca 90% ee, was the key step in each of the syntheses. Enantioselectivity was increased i