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Synthesis of butenolides via enantioselective deprotonation of protected 4-hydroxycyclohexanone

โœ Scribed by Marek Majewski; Nicholas M. Irvine; John MacKinnon


Book ID
108036316
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
222 KB
Volume
6
Category
Article
ISSN
0957-4166

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Synthesis of tropane alkaloids darlingine, chalcostrobamine and isobellendine both in the racemic form and as unnatural enantiomers is described. Enantioselective deprotonation of tropinone, which proceeded with ca 90% ee, was the key step in each of the syntheses. Enantioselectivity was increased i