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Synthesis of tritium labelled verrucarol and verrucarin a

✍ Scribed by Boris Yagen; Bruce B. Jarvis

Publisher: John Wiley and Sons
Year: 1989
Tongue: French
Weight: 332 KB
Volume: 27
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580270610

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✦ Synopsis

Two tritium labelled trichothecenes, vermcarol(2) and verrucarin A (5) were synthesized with high specific activity. Oxidation of vermcarol(1) to the 15dehydrovermcarol(3) followed by sodium borotritide reduction yielded [ W3H]vermcarol(2). Reduction of 16mesyloxyvermcarin A (7) in a special bufferorganic solvent system with a phase transfer catalyst, produced [16-3H]vermcarin A (5). Final purification of the radioactive products was achieved by preparative thin layer chromatography. Their structures were assigned based on the analytical data of the corresponding nonradiolabelled compounds obtained from the nonradioactive preparations.

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