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Synthesis of tritium labelled CCK4 (Trp-Met-Asp-[3H]Phe-NH2)

✍ Scribed by B. Charpentier; B. P. Roques; J. Roy; J. L. Morgat

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
307 KB
Volume
27
Category
Article
ISSN
0022-2135

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✦ Synopsis

CCK4 ( C C K

) is t h e s h o r t e s t fragment of c h o l e c y s t o k i n i n which r e t a i n s a high a f f i n i t y (nanomolar r a n g e ) f o r b r a i n CCK r e c e p t o r s . I n o r d e r t o determine wether CCKQ i n t e r a c t s w i t h b i n d i n g sites d i s t i n c t from t h o s e o f CCK8, [ HICCK,, was s y n t h e s i z e d . T h i s p e p t i d e was prepared i n l i q u i d phase u s i n g L-3(3' ,4' ,5' -t r i b r o m o p h e n y l ) a l a n i n e as t h e phenylalanine p r e c u r s o r .

The r e d u c t i v e t r i t i a t i o n o f H-Trp-Met-Asp-Phe(Br) -NH was performed u s i n g PdO a s t h e c a t a l y s t t o y i e l d [ H]CCK4 w i t h a s p e c i f i c a c t i v i t y of 35 Ci/mmol ( 1 295 GBq/mrnol).

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