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Synthesis of tritium and deuterium labeled 8-N-n-butyl-N-methylamino-8-(3-hydroxyphenyl)-1,4-dioxaspiro[4,5]decane hydrochloride

✍ Scribed by Richard S. P. Hsi; Richard R. Kurtz; Malcolm W. Moon

Publisher: John Wiley and Sons
Year: 1987
Tongue: French
Weight: 375 KB
Volume: 24
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580241115

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✦ Synopsis

The title compound, a 4-amino-4-arylcyclohexanone derivative with central analgesic activit was labeled with tritium at the C-7 and C-9 positions. Deuterium lakeled intermediates were used as models for developing isotope exchange and synthetic procedures. Deuterium and tritium labeled title compounds were obtained in five steps with overall yields of 18-22% from 1,4dioxaspiro[4,S]-decan-8-one and 3bromophenol.

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