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ChemInform Abstract: Synthesis of N-(4-Aryl-1-piperazinylbutyl)-substituted 7,8-Benzo-1,3-diazaspiro[4,5]decane-2,4-dione Derivatives with Potential Anxiolytic Activity.

✍ Scribed by J. KOSSAKOWSKI; T. ZAWADOWSKI; J. TURLO; J. KLEPS

Publisher: John Wiley and Sons
Year: 2010
Weight: 37 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199834180

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✦ Synopsis

Synthesis of N-(4-Aryl-1-piperazinylbutyl)-substituted 7,8-Benzo-1,3diazaspiro[4,5]decane-2,4-dione Derivatives with Potential Anxiolytic Activity.

-A series of new derivatives of 7,8-benzo-1,3-diazaspirodecane-2,4-dione bearing a piperazinylbutyl group at one imide nitrogen (V) (6 examples) are synthesized from the corresponding N-unsubstituted heterocycle (I). Compound (Va), the only derivative submitted to the 5-HT 1A receptor binding assay, displays the expected, but rather weak receptorial affinity. -(KOSSAKOWSKI,

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