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Synthesis of Trisaccharide Moieties from N-Acetylneuraminic Acid and N-Acetyllactosamine

✍ Scribed by Prof. Dr. Hans Paulsen; Holger Tietz


Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
204 KB
Volume
21
Category
Article
ISSN
0044-8249

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A new synthesis of N-acetylneuraminic acid (NeuSAc; 28) via the aldehyde 10 is described. The aldehyde 10 was obtained from N-acetyl-o-glucosamine (11; 5 steps, overall yield ca. 6 %) or from o-glucono-1,s-lactone (17; 6 steps, overall yield ra. 57%). Thus, on the one hand, N-acetyl-D-mannosamine (1

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