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Synthesis of tricylic systems incorporating the azepine ring

โœ Scribed by O. V. Shekhter; A. S. Chernyak; N. L. Sergovskaya; Yu. S. Tsizin; F. S. Mikhailitsyn; S. K. Drusvyatskaya; N. A. Uvarova

Publisher
Springer US
Year
1990
Tongue
English
Weight
433 KB
Volume
26
Category
Article
ISSN
0009-3122

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Versatile assembly of the 2-carboxybenzo
Versatile assembly of the 2-carboxybenzo[b]azepine ring system
โœ Simone A Giacobbe; Romano Di Fabio ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 85 KB

A suitable 2-carboxybenzo[b]azepine derivative was designed as a potential novel antagonist of the strychnine-insensitive glycine binding site of the NMDA receptor. This compound was synthesized via an N-aryl allylglycine, a useful intermediate efficiently prepared from the starting aniline derivati