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Versatile assembly of the 2-carboxybenzo[b]azepine ring system

✍ Scribed by Simone A Giacobbe; Romano Di Fabio

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
85 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

A suitable 2-carboxybenzo[b]azepine derivative was designed as a potential novel antagonist of the strychnine-insensitive glycine binding site of the NMDA receptor. This compound was synthesized via an N-aryl allylglycine, a useful intermediate efficiently prepared from the starting aniline derivative, followed by a short and unusual elaboration of the allyl double bond.

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