An approach to the synthesis of peptide–
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Martijn C de Koning; Dmitri V Filippov; Nico Meeuwenoord; Mark Overhand; Gijs A
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Article
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2002
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Elsevier Science
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French
⚖ 150 KB
A convenient solid-phase synthesis of a PNA sequence containing an N-terminal thiaproline and a C-terminal thioester is described. The usefulness of this bifunctional PNA molecule is illustrated by the construction, based on native ligation, of a peptide-PNA-peptide adduct.