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Synthesis of thromboxane receptor antagonists with the potential to radiolabel with 125I

✍ Scribed by D. Mais; D. Knapp; P. Halushka; K. Ballard; N. Hamanaka

Book ID
104233763
Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
179 KB
Volume
25
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of several thromboxane receptor antagonists is described along with their ability to inhibit aggregation of human platelets.

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✍ Dale E. Mais; Perry V. Halushka πŸ“‚ Article πŸ“… 1988 πŸ› John Wiley and Sons 🌐 French βš– 257 KB πŸ‘ 1 views

The synthesis o f [1251]-( 1S,2S,3S,5R)-2-(6~-carboxyhex-(2~Z)enyl)-3-(2-hydroxy-3-(4-hydroxy-3-iodophenyl)-l-propyl ami n0)-6,6-dimethyl b i c y c l o[ 3.1.13 heptane( I-PTA-OH), a h i g h a f f i n i t y thromboxane A /prostaglandin H (TXA /PGH ) receptor antag o n i s t has been p r e v i o u s l