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Synthesis of the β-lactam antibiotic (+)- thienamycin via an intermediate π-allyltricarbonyliron lactone complex

✍ Scribed by Simon T. Hodgson; David M. Hollinshead; Steven V. Ley


Book ID
108372653
Publisher
Elsevier Science
Year
1985
Tongue
French
Weight
970 KB
Volume
41
Category
Article
ISSN
0040-4020

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The BO-2502A side chain intermediate 3 was prepared via the diastereoselective lactamization of the in situ prepared amino diacid anhydride 14 as a key step. The diastereoselectivity of this step was found to be 53:1 (96% de).