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Synthesis of the spiroketal segment (C19C34) of the rutamycins, antifungal metabolites of Streptomyces species

✍ Scribed by James D. White; Yoshihiro Ohba; Warren J. Porter; Shan Wang

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
170 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

A convergent synthesis of the spiroketal subunit of rutamycins A and B has been devised via Julia coupling of sulfone 14 with aldehyde 23; the pentahydroxy ketone 3 derived from 25 underwent spontaneous cyclization to spiroketal 4.

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