Synthesis of the sesquiterpenoid trichodiene using a free radical fragmentation approach

✍ Scribed by Gordon L Lange; Lorena Furlan; Mark C MacKinnon

• Book ID: 104259597
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 147 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)01140-x

✦ Synopsis

A highly regio-and stereoselective synthesis of the sesquiterpenoid trichediene is reported. The approach requires only nine steps starting with a [2+2] photoaddition and employs the free radical fragmentation of an "external" cyclobutane bond in a key step.