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Synthesis of the rice herbicide HW-52 [dichlorophenyl ring 14C(U)]

✍ Scribed by Ikuo Kimura; Norimasa Yokoyama; Kaoru Kasahara; Takao Ueda; Kazunori Atsumi; Crist Filer; Christopher Wright

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
307 KB
Volume
33
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

^14^C‐Labeled 2′,3′‐dichloro‐4‐(ethoxymethoxy) benzanilide (HW‐52) (10) was synthesized in a total of 9 steps from 1, 3‐dinitrobenzene [^14^C(U)]. The key intermediate 2,3‐dichloroaniline [^14^C(U)] (7) was prepared from the starting material by a series of aromatic substitutions and functional group manipulations. Conversion to the final product was achieved in high yield by coupling and further functional group manipulations. The overall radiochemical yield was 1.88% and radiochemical purity of the product was greater than 98.8%.

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The synthesis of [ring-U-14C] DDD from [
The synthesis of [ring-U-14C] DDD from [ring-U-14C] DDT using rat liver homogenate
✍ S. C. Fawcett; L. J. King; P. I. Stanley; P. J. Bunyan 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 164 KB

## Abstract 1,1‐Di[__ring__‐U‐^14^C] (4‐chlorophenyl)‐2,2‐dichloroethane ([^14^C] DDD) was prepared by the anaerobic incubation of 1,1‐di[__ring__‐U‐^14^C] (4‐chlorophenyl)‐2,2,2‐trichloroethane ([^14^C] DDT) with homogenised rat liver in buffer. This gave a good yield of DDD which was purified chr