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Synthesis of the Potent Antiglaucoma Agent, Travoprost

✍ Scribed by Boulton, Lee T.; Brick, Dean; Fox, Martin E.; Jackson, Mark; Lennon, Ian C.; McCague, Raymond; Parkin, Nicholas; Rhodes, Darren; Ruecroft, Graham

Book ID
118263028
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
107 KB
Volume
6
Category
Article
ISSN
1083-6160

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## Abstract Starting from [^14^C] ethyl orthoformate and amidine derivative 3 derived from griseolic acid in 6 steps, the synthesis of [2‐^14^C] griseolic acid 9′‐(4‐acetoxy‐3‐gethoxybenzyl)ester [14C]‐2, a promising antiglaucoma agent with its regioisomer [2‐^14^C] griseolic acid 8′‐(4‐acetoxy‐3‐g