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Synthesis of the Optical Isomers of a New Anticholinergic Drug, Penehyclidine Hydrochloride (8018).

✍ Scribed by Xiang-Yu Han; He Liu; Chun-He Liu; Bo Wu; Lan-Fu Chen; Bo-Hua Zhong; Ke-Liang Liu

Publisher: John Wiley and Sons
Year: 2005
Weight: 18 KB
Volume: 36
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200533162

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✦ Synopsis

Pyridine derivatives with bridges R 0460

Synthesis of the Optical Isomers of a New Anticholinergic Drug, Penehyclidine Hydrochloride (8018). -A facile and efficient procedure to prepare the four isomers of the title compound 8018 (VI) employing the asymmetric epoxidation of mono-sulfonate (III) as the key step is developed.

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