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Synthesis of the melanoma-associated ganglioside 9-O-acetyl GD3 through regioselective enzymatic acetylation of GD3 using subtilisin

✍ Scribed by Shuichi Takayama; Philip O Livingston; Chi-Huey Wong

Book ID: 104258721
Publisher: Elsevier Science
Year: 1996
Tongue: French
Weight: 208 KB
Volume: 37
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)82939-5

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✦ Synopsis

The melanoma-associated disialoganglioside 9-O-acetyl GD3 has been synthesized for the first time through regioselective enzymatic acetylation of GD3 using subtilisin as the biocatalyst and vinyl acetate as the acetyl donor.

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