Synthesis of the L-arginine congener L-Indospicine and evaluation of its interaction with nitric oxide synthase
β Scribed by Paul L. Feldman; Shannon Chi; Nicolas Sennequier; Dennis J. Stuehr
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 221 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0960-894X
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## Abstract **BACKGROUND:** To test whether the differentiating embryo is susceptible to the teratogenic effects of the nitric oxide (NO) synthesis inhibitor N^G^βnitroβLβarginine methyl ester (LβNAME). **METHODS:** ICRβ(CDβ1) mice received a single intraperitoneal injection of LβNAME at 90, 150, o
Department ot Internal Medicme, U n i i w ~z t v of We used the single-pass-perfused rat liver model to study short-term regulation of endotoxin-inducible nitric oxide synthesis by following the release of nitrite and nitrate, the oxidation products of nitric oxide, into the effluent perfusate. In e