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Synthesis of the L-Acid (C1–C18) Fragment of Pamamycin-593 and De-N-methylpamamycin-579

✍ Scribed by Ayako Miura; Shin-ya Takigawa; Yukito Furuya; Yusuke Yokoo; Shigefumi Kuwahara; Hiromasa Kiyota


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
254 KB
Volume
2008
Category
Article
ISSN
1434-193X

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✦ Synopsis


Abstract

The L‐acid (C1–C18) fragment of pamamycin‐593 and de‐N‐methylpamamycin‐579, strong aerial mycelium‐inducers of Streptomyces alboniger, was synthesized using a cis‐selective iodoetherification and a nucleophilic addition of a cerium acetylide to an aldehyde as the key steps. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)


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