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Synthesis of the ketodifluoromethylene dipeptide isostere

✍ Scribed by Damon, David B.; Hoover, Dennis J.


Book ID
126008968
Publisher
American Chemical Society
Year
1990
Tongue
English
Weight
600 KB
Volume
112
Category
Article
ISSN
0002-7863

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A general stereo-directed synthesis of "ketomethylene" and "hydroxyethylene" dipeptide isosteres is reported. Peptides containing the amino acids, (2&%)-5-amino-4-oxo-2,8dimethyloctanoic acid (the "ketomethylene" analog of L-Leu-L-Ala), and (2&,5z)-5-amino-4-hydroxy-2,8-dimethyloctanoic acid (the "h