Synthesis of hydroxyethylene and ketomet
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Mark W. Holladay; Daniel H. Rich
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Article
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1983
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Elsevier Science
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French
β 210 KB
A general stereo-directed synthesis of "ketomethylene" and "hydroxyethylene" dipeptide isosteres is reported. Peptides containing the amino acids, (2&%)-5-amino-4-oxo-2,8dimethyloctanoic acid (the "ketomethylene" analog of L-Leu-L-Ala), and (2&,5z)-5-amino-4-hydroxy-2,8-dimethyloctanoic acid (the "h