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Dipeptide analogs. Versatile synthesis of the hydroxyethylene isostere

✍ Scribed by Kempf, Dale J.


Book ID
121469790
Publisher
American Chemical Society
Year
1986
Tongue
English
Weight
852 KB
Volume
51
Category
Article
ISSN
0022-3263

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πŸ“œ SIMILAR VOLUMES


Synthesis of hydroxyethylene and ketomet
✍ Mark W. Holladay; Daniel H. Rich πŸ“‚ Article πŸ“… 1983 πŸ› Elsevier Science 🌐 French βš– 210 KB

A general stereo-directed synthesis of "ketomethylene" and "hydroxyethylene" dipeptide isosteres is reported. Peptides containing the amino acids, (2&%)-5-amino-4-oxo-2,8dimethyloctanoic acid (the "ketomethylene" analog of L-Leu-L-Ala), and (2&,5z)-5-amino-4-hydroxy-2,8-dimethyloctanoic acid (the "h