Synthesis of the isomeric phenols of benz[a]anthracene from benz[a]anthracene
โ Scribed by Fu, Peter P.; Cortez, Cecilia; Sukumaran, K. B.; Harvey, Ronald G.
- Book ID
- 126322836
- Publisher
- American Chemical Society
- Year
- 1979
- Tongue
- English
- Weight
- 975 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0022-3263
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The synthesis of the potent carcinogen 7,12-dimethylbenzCa]anthracene, DMBA, 4a and its many derivatives has been difficult in the past due to the lack of commercially available starting materials. Of the various methods available for its synthesis (l-4) , the simplest involves the addition of methy
Polycyclic aromatic hydrocarbons (PAR) are metabolized primarily by enzymatic oxyganation which converts the hydrocarbons into polycyclic phenols, dihydrodiols, quinones, etc., and water-soluble conjugates. 1 These metabolites are thought to be formed via eporfde intermedi-2 ates, which readily iso