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Synthesis of the hydroxyethylene isostere of Leu-Val

✍ Scribed by Wuts, Peter G. M.; Ritter, Allen R.; Pruitt, Lynn E.


Book ID
120255735
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
692 KB
Volume
57
Category
Article
ISSN
0022-3263

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Synthesis of hydroxyethylene and ketomet
✍ Mark W. Holladay; Daniel H. Rich πŸ“‚ Article πŸ“… 1983 πŸ› Elsevier Science 🌐 French βš– 210 KB

A general stereo-directed synthesis of "ketomethylene" and "hydroxyethylene" dipeptide isosteres is reported. Peptides containing the amino acids, (2&%)-5-amino-4-oxo-2,8dimethyloctanoic acid (the "ketomethylene" analog of L-Leu-L-Ala), and (2&,5z)-5-amino-4-hydroxy-2,8-dimethyloctanoic acid (the "h