Lipase from Candida rugosa immobilized on a nylon support has been used to synthesize lovastatin, a drug which lowers serum cholesterol levels, by the regioselective acylation of a diol lactone precursor with 2methylbutyric acid in mixtures of organic solvents. Analogs of lovastatin having a differe
✦ LIBER ✦
Synthesis of the ‘green apple ester’ ethyl valerate in organic solvents by Candida rugosa lipase immobilized in MBGs in organic solvents: Effects of immobilization and reaction parameters
✍ Scribed by Tripti Raghavendra; Divya Sayania; Datta Madamwar
- Book ID
- 113804593
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 584 KB
- Volume
- 63
- Category
- Article
- ISSN
- 1381-1177
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## Abstract Lipase‐catalyzed enantioselective esterification between (__R__,__S__)‐ketoprofen and alkanediol in organic solvents was developed to produce (__S__)‐ketoprofen hydroxyalkyl esters. The acyl acceptor of 1,6‐hexanediol for the resolution of (__R__,__S__)‐ketoprofen yielded only the enant