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Synthesis of the esters of 1-alkyl-2-aminoindolyl-3-acetic acids by the kost reaction

✍ Scribed by V. P. Zhestkov; V. G. Zabrodnaya; A. I. Chernyshev


Publisher
Springer US
Year
1995
Tongue
English
Weight
428 KB
Volume
31
Category
Article
ISSN
0009-3122

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## Abstract Reaction of (βˆ’)‐(__S__)‐methyl 2‐bromopropionate (**4**) (obtained from l‐alanine) with dibenzyl ethylmalonate gave stereospecifically in four steps ( + )‐(2__R__,3__S__)‐2‐ethyl‐3‐methylsuccinic acid (**8a**) and its diastereoisomer (**8b**). The malonic ester alkylation proceeded with