## Abstract The radiochemical synthesis of the high affinity, selective sigma receptor ligand, N^1^‐3‐[^18^F]Fluoropropyl‐N^4^‐2‐([3,4‐dichlorophenyl]ethyl)piperazine, is reported. The labeled compound is prepared by fluoride displacement on a bismethanesulfonate salt of the propyl methanesulfonylo
✦ LIBER ✦
Synthesis of the dopamine-D4 receptor ligand (3-(4-[18F]fluoro-phenoxy)propyl)-(2-(4-tolylphenoxy)ethyl)amine via optimized N.C.A. 4-[18F]fluorophenol
✍ Scribed by Th. Ludwig; J. Ermert; H. H. Coenen
- Book ID
- 112132531
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- French
- Weight
- 149 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0022-2135
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## Abstract 4‐Fluoro‐__N__‐{2‐[4‐(6‐trifluoromethylpyridin‐2‐yl)piperazin‐1‐yl]ethyl}benzamide is a full 5‐HT~1A~ agonist with high affinity (__pK__~__i__~=9.3), selectivity and a __c__ log __P__ of 3.045. The corresponding PET radioligand 4‐[^18^F]fluoro‐__N__‐{2‐[4‐(6‐trifluoromethylpyridin‐2‐yl)