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Synthesis of the Dinucleotide Spore Photoproduct

โœ Scribed by Kim, Seong Jin; Lester, Cathy; Begley, Tadhg P.


Book ID
126905425
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
186 KB
Volume
60
Category
Article
ISSN
0022-3263

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Synthesis of the spore photoproduct
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The spore photoproduct was synthesized in seven steps from dihydrothymine and 5-formyluracil using a mixed Aldol coupling as the key bond forming step.

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## Abstract Investigation of the DNA repair process performed by the spore photoproduct (SP) lyase repair enzyme is strongly hampered by the lack of defined substrates needed for detailed enzymatic studies. The problem is particularly severe because the repair enzyme belongs to the class of strongl